In Vivo Imaging of Pigmentary Disorders by Reflectance Confocal Microscopy
Stopped early
Conditions studied: Vitiligo, Melasma, Hyperpigmentation, Hypopigmentation
In brief
This is a pilot study to evaluate the findings of the Reflectance Confocal Microscopy when performed in cutaneous pigmentary disorders, such as vitiligo, melasma, post-inflammatory hyper-pigmentation and hypo-pigmentation. Confocal Microscopy is a recent diagnostic technique that has been used for observation of skin conditions that affect the superficial layers of the skin.
Key facts
- Study ID
- NCT00771355
- Run by
- Massachusetts General Hospital
- People needed
- 40
- Starts
- 2008-08-01
- Expected to finish
- 2010-07-01
- Last updated by the study team
- 2011-03-30
Who can join
Age: 20 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Subjects 20-70 years of age.
- Clinical diagnosis of vitiligo, melasma, post-inflammatory hypo or depigmentation or post-inflammatory hyperpigmentation.
- Willing and able to understand and sign informed consent.
- Able to complete study and comply with study procedures.
You may not qualify if…
- Use of topical therapies such as corticosteroids, protopic, hydroquinone and azelaic acid within the past 2 months.
- Use of light therapy such as narrow-band-UVB, PUVA or laser within the past 2 months.
- Intake of medications that can cause pigmentary changes within the past year. Examples are:
- Antimalarials (chloroquine, hydroxychloroquine)
- Chemotherapeutics (bleomycin, busulfan, doxorubicin, daunorubicin, fluorouracil, cyclophosphamide, and carmustine)
- Heavy metals (gold, silver, bismuth, and mercury)
- Tetracyclines (including minocycline, doxycycline)
- Amiodarone
- Azidothymidine
- Clofazimine
- Clinically significant abnormal findings or conditions (other than the pigmentary disorder), which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.
- Subjects who are known to be pregnant or planning a pregnancy.
Where it is running
- Clinical Unit for Research Trials in Skin — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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