Exercise Dose and Nonalcoholic Fatty Liver Disease

Completed · Not applicable

Conditions studied: Non-alcoholic Fatty Liver Disease (NAFLD)

In brief

The purpose of this research is to provide a better understanding of how exercise (walking) affects non-alcoholic fatty liver disease (NAFLD) in overweight people. NAFLD, which is common in obese people, occurs when the liver has too much fat.

Key facts

Study ID

NCT00771108

Run by

Washington University School of Medicine

People needed

33

Starts

2006-05-01

Expected to finish

2011-04-01

Last updated by the study team

2011-09-07

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-65 with Nonalcoholic Fatty Liver Disease as determined by MRS

You may not qualify if…

• Medical History
• Diabetes
• Heart Disease
• Asthma/Lung disease
• Injury that prevents exercise
• Social history
• Drinking
• More than one drink per day
• Binge drinking on the weekends (more than 3 or 4 drinks per weekend day)
• Smoking
• It's OK if they were a previous smoker, but they need to have quit more than 6 months ago
• Exercise
• They must exercise less than one hour per week
• Medications: must be on stable regimen of ANY medication for at least 3 months
• Beta-Blockers
• Lipid/cholesterol lowering medications:
• Oral hypoglycemics (anti-diabetes medications - some like metformin are indicated for pre-diabetes)
• Hormone replacement therapy
• If the woman is pre-menopausal, it is OK if she is on birth control as long as she has been on it over 3 months
• Weight history
• Weight <300 lbs
• BMI 30 to 45
• Weight stable - <10lbs weight loss or gain in the last 3 months

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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