ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Completed · Phase 1
Conditions studied: Brain and Central Nervous System Tumors
In brief
RATIONALE: ABT-888 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving ABT-888 together with radiation therapy and temozolomide may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of ABT-888 when given together with radiation therapy and temozolomide and to see how well it works in treating patients with newly diagnosed glioblastoma multiforme.
Key facts
- Study ID
- NCT00770471
- Run by
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- People needed
- 24
- Starts
- 2009-07-13
- Expected to finish
- 2012-03-01
- Last updated by the study team
- 2018-06-27
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Josephine Ford Cancer Center at Henry Ford Hospital — Detroit, Michigan, United States
- Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
- Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
- Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
- UPMC Cancer Centers — Pittsburgh, Pennsylvania, United States
- University of Wisconsin Comprehensive Cancer Center — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.