Optic Discs in Children With Cerebral Palsy

Completed

Conditions studied: Cerebral Palsy

In brief

Hypothesis: Children born prematurely (between 8 and 9 months) with brain damage have an abnormal appearance of the optic nerve (nerve in eye) that resembles glaucoma (cupping) compared to those born before 8 months. Purpose: to see how often children who are born prematurely and have suffered brain damage, have abnormal appearance of the optic nerve (nerve in the eye) which mimics glaucoma (cupping). This optic nerve cupping is most often seen when children are born after 8 months and is rarely seen in children born before 8 months. Children born prematurely are known to have injuries to their brain as they are not yet fully developed. This often involves the part of the brain that involves vision. Clinicians have observed that these children have an abnormal appearance of the optic nerve (nerve in the eye), which has the appearance of glaucoma. These children often undergo extensive and often unnecessary invasive tests to rule out glaucoma. The investigators wish to establish the prevalence of this abnormality so that children are not subjected to unnecessary investigations. The investigators also want to understand how the optic nerve cupping (similar clinical picture as glaucoma) is related to the approximate timing and extent of the brain injury, the type of cerebral palsy and the motor disability of these children.

Key facts

Study ID

NCT00769197

Run by

University of Mississippi Medical Center

People needed

61

Starts

2008-06-01

Expected to finish

2009-01-01

Last updated by the study team

2009-04-29

Who can join

Age: 0 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children born prematurely at age 24-36 weeks of gestation; are currently in the age group 0-17 years and enrolled in Dr Vedanarayanan's pediatric neurology clinic.
• Diagnosis of static encephalopathy, cerebral palsy or CNS malformations
• Availability of CT head or MRI brain for review.

You may not qualify if…

• Parents/guardians or the child refuse consent or assent.
• Presence of ocular media opacities preventing visualization of the fundus
• The child is unable to cooperate for the ocular examination.
• Coexistent diagnosis of glaucoma
• Unable to obtain perinatal history from parents/guardians or records

Where it is running

• University of Mississippi Medical Center — Jackson, Mississippi, United States

Full record on ClinicalTrials.gov

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