A Bioavailability and Safety Study of Probuphine Versus Sublingual Buprenorphine in Patients With Opioid Dependence

Stopped early · Phase 3

Conditions studied: Opioid Dependence

In brief

This study will measure the amount of buprenorphine found in the blood after taking sublingual buprenorphine tablets versus after implantation with 4 Probuphine (buprenorphine implants).

Key facts

Study ID

NCT00768482

Run by

Titan Pharmaceuticals

People needed

9

Starts

2008-09-01

Expected to finish

2008-12-01

Last updated by the study team

2018-12-31

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Voluntarily provide written informed consent prior to the conduct of any study related procedures
• Male or female, 18-75 years of age
• Meet the DSM-IV criteria for current opioid dependence
• Females of childbearing potential and fertile males must use a reliable means of contraception

You may not qualify if…

• Current diagnosis of Acquired Immune Deficiency Syndrome (AIDS)
• Received treatment for opioid dependence (e.g., methadone, BPN) within the previous 90 days
• Current diagnosis of chronic pain requiring opioids for treatment
• Candidates for only short term opioid treatment or opioid detoxification therapy
• Pregnant or lactating females
• Previous hypersensitivity or allergy to BPN or EVA-containing substances or naloxone
• Current use of agents metabolized through Cytochrome P450 3A4 (CYP 3A4) such as azole antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., erythromycin), and protease inhibitors (e.g., ritonavir, indinavir, and saquinavir)
• Current history of coagulopathy, and/or anti-coagulant therapy (such as warfarin)
• Meet the DSM-IV criteria for current dependence on any other psychoactive substances other than opioids or nicotine (e.g., alcohol, sedatives)
• Current use of benzodiazepines other than physician prescribed use
• Significant medical or psychiatric symptoms, cognitive impairment, or other factors which in the opinion of the Investigators would preclude compliance with the protocol, patient safety, adequate cooperation in the study, or obtaining informed consent
• Concurrent medical conditions (such as severe respiratory insufficiency) that may prevent the patient from safely participating in study; and/or any pending legal action that could prohibit participation and/or compliance in study
• Participated in a clinical study within the previous 8 weeks
• Previous participation in a Probuphine clinical trial
• Presence of aspartate aminotransferase (AST) levels greater than or equal to 3 X upper limit of normal and/or alanine aminotransferase (ALT) levels greater than or equal to 3 X upper limit of normal and/or total bilirubin greater than or equal to 1.5 X upper limit of normal and/or creatinine greater than or equal to 1.5 X upper limit of normal
• Clinically significant low platelet count with current history of coagulopathy

Where it is running

• Segal Institute For Clinical Research — Fort Lauderdale, Florida, United States

Full record on ClinicalTrials.gov

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