DNA Diagnostic System for Statin Safety and Efficacy

Status unconfirmed

Conditions studied: Hypercholesterolemia, Myopathy

In brief

Lipitor®, Zocor®, and Crestor® are statin drugs commonly taken to lower cholesterol and prevent heart disease. Statins lower cholesterol by different amounts in different patients and sometimes statins cause muscle pain, cramps, or weakness. This study will examine genetic differences in the blood of patients taking statins to predict both how well the statins lower cholesterol, and whether muscle discomfort occurs. Finding such genetic connections is the key to developing genetic tests that might eventually help determine which statin is best for a patient. About 1000 people will be in the study.

Key facts

Study ID

NCT00767130

Run by

Genomas, Inc

People needed

750

Starts

2007-01-01

Expected to finish

2009-12-01

Last updated by the study team

2008-10-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• receiving, or documented to have received in the past, any of the statins including atorvastatin, simvastatin, rosuvastatin treatment for hypercholesterolemia
• chart-documented clinical record of having had, never having had, or possibly having had, statin-associated myopathy

You may not qualify if…

• never having taken any statin medication

Where it is running

• University of California-San Francisco — San Francisco, California, United States (enrolling)
• Hartford Hospital — Hartford, Connecticut, United States (enrolling)
• Rogosin Institute, New York Presbyterian Hospital — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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