Muscle Lipid and Insulin Resistance in the Elderly

Completed · Not applicable

Conditions studied: Obesity

In brief

This project will provide novel information concerning the ability of exercise to enhance the capacity for oxidative metabolism of fatty acids and improve insulin resistance in older adults who are at high risk for the development of type 2 diabetes. Ultimately this may help identify mechanisms and therapeutic targets implicated in skeletal muscle metabolic dysregulation. The proposed study is to conduct a randomized controlled exercise training intervention trial in older men and women. In addition, the response to exercise in these subjects will be compared to those of highly endurance-trained, age-matched athletes.

Key facts

Study ID

NCT00765505

Run by

University of Pittsburgh

People needed

92

Starts

2004-07-01

Expected to finish

2017-12-31

Last updated by the study team

2018-02-06

Who can join

Age: 60 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 60 - 70 years of age
• No weight gain/loss of >10 lbs in 6 months
• Sedentary (No more than 1 continuous exercise/week) or Highly trained (>5 exercise sessions/week for a duration of one year or more)
• Non-Smoker
• BMI 18-38.0
• Resting blood pressure less than 150mmHg systolic/95 mmHg diastolic
• Normal glucose tolerance: Fasting glucose < 100 mg/dl or 2 hour glucose from OGTT < 140 mg/dl or impaired glucose tolerance (fasting glucose > 100 mg/dl < 126 mg/dl or 2 hour glucose from OGTT > 140 mg/dl but less than 200 mg/dl
• Note from PCP/Cardiologist for exercise clearance if positive stress test symptoms were observed from GXT

You may not qualify if…

• Clinically significant CVD including h/o MI
• Peripheral Vascular Disease
• Hepatic, renal, muscular/neuromuscular, or active hematologic/oncologic disease
• Clinically diminished pulse
• Presence of bruits in lower extremities
• Previous history of pulmonary emboli
• Peripheral Neuropathy
• Currently not engaged in a regular program and have a V)2 max pre-training value > 55 ml/kg-fat free mass-min., indicative of moderate fitness OR currently engaged in regular program and having a V)2 max value < 55 ml/kg-fat free mass-min.
• Anemia (Hematocrit < 34%)
• Any contraindications to moderate exercise
• Inability and/or willingness to comply with the protocol as written
• Active alcohol or substance abuse (Past 5 years)
• Total cholesterol > 300 mg/dL
• Triglyceride > 350 mg/dL
• ALT > 80, AST > 80, Alk Phos > 240
• Proteinuria (defined as > 1+ on routine dipstick) hypothyroidism (sTSH>8)
• Therapeutic Doses of Nicotinic Acid
• Type 2 Diabetes: Fasting Glucose > 126 mg/dl or 2 hour glucose > 200 mg/dl
• Oral Glucocorticoids
• Females currently on hormone replacement therapy (HRT) less than 6 months
• Claustrophobia
• Previous difficulty with lidocaine or other local anesthetic
• Stress test symptoms:
• Positive ECG (>2mm ST segment depression) without PCP cardiologist permission to participate
• Signs or symptoms of cardiovascular decomposition (hypotensive response to exercise

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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