Blood Samples to Evaluate Biomarkers of Donor Chimerism

Completed

Conditions studied: Leukemia, Hodgkins Disease, Non-hodgkins Lymphoma, Myelodysplastic Syndrome

In brief

We are interested in patient-specific factors that may affect the balance of recipient cells and donor cells in patients who receive stem cell transplants. We will look at the way the patient's body breaks down two drugs, fludarabine and mycophenolate mofetil, and how these two drugs affect the patient's body.

Key facts

Study ID

NCT00764829

Run by

Fred Hutchinson Cancer Center

People needed

80

Starts

2008-09-01

Expected to finish

2012-02-01

Last updated by the study team

2012-02-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with a hematologic disease or malignancy
• Scheduled to receive nonablative conditioning with fludarabine and total body irradiation
• Donor is well-matched by high resolution DNA techniques.
• Scheduled to receive postgrafting immunosuppression of oral MMF (CellCept) and an oral calcineurin inhibitor.
• Age >18 years at the time of enrollment.

You may not qualify if…

• Diagnosed with an immunodeficiency disorder

Where it is running

• Fred Hutchinson Cancer Research Center — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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