Effect of Dietary Protein Source on Phosphaturia, PTH and FGF23 in Patients With CKD 3 and 4
Completed · Not applicable
Conditions studied: Chronic Kidney Disease
In brief
Phosphorus is a substance in the blood that comes from food and is normally cleared from the body by the kidneys. In patients with kidney disease, excess phosphorus may build up in the body as you eat. This leads to problems with bones and blood vessels over time. In this study, we will compare the blood and urine before and after eating one week of a diet with a protein from plants (soy and grains) and before and after another one week of diet with protein from animals (meat and dairy products). The amount of phosphorus that the kidney puts out in the urine, and the changes in blood hormones in response to the diet will be measured at the beginning and end of each week on the two diets.
Key facts
- Study ID
- NCT00764816
- Run by
- Indiana University
- People needed
- 9
- Starts
- 2008-10-01
- Expected to finish
- 2011-02-01
- Last updated by the study team
- 2011-06-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age >18 years
- eGFR 20-45 by modified MDRD equation
- protein/creatinine ratio <5
- blood pressure <150/95
- not taking calcium binder or supplements, vitamin D, or phosphate binders
- normal serum phosphorus and calcium corrected for albumin and intact PTH <100pg/ml
- medically stable
- able to give informed consent and come for all visits
You may not qualify if…
- history of significant liver disease or cirrhosis
- medically unstable
- unable to tolerate diets
Where it is running
- Indiana University School of Medicine — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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