Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis in Patients With HIV?

Completed

Conditions studied: Latent Tuberculosis, HIV Infections

In brief

HIV infection highly increases the risk of progression of latent tuberculosis (TB) to active disease that therapy is recommended for all PPD-positive, HIV-infected patients, regardless of age. Sensitivity of the PPD testing is, however, dependent on a normal T cell function. Therefore, an accurate and reliable method for detection of latent tuberculosis in patients with HIV is urgently needed. This prospective study will examine the utility of interferon-gamma (IFN-γ) based assay, T-SPOT.TB,for detection of TB in HIV-infected individuals.

Key facts

Study ID

NCT00763295

Run by

Northwell Health

People needed

53

Starts

2008-05-01

Expected to finish

2010-01-01

Last updated by the study team

2012-10-26

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• adult individuals with confirmed HIV infection

You may not qualify if…

• Patients who are on INH treatment
• Patients who have a positive PPD test within 1 year of study enrollment
• Individuals with blistering or ulcerating skin disorder
• Pregnant women
• Patients who were given blood transfusion within 6 weeks prior to enrollment

Where it is running

• Staten Island University Hospital — Staten Island, New York, United States

Full record on ClinicalTrials.gov

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