Study of the Medication Prazosin for Alcohol Dependence

Completed · Phase 2 · Has a placebo group

Conditions studied: Alcoholism

In brief

The purpose of this study is to determine whether the drug prazosin is effective for the treatment of alcohol dependency.

Key facts

Study ID

NCT00762710

Run by

Seattle Institute for Biomedical and Clinical Research

People needed

92

Starts

2008-01-01

Expected to finish

2014-06-01

Last updated by the study team

2020-06-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current primary DSM-IV diagnosis of alcohol dependence(AD)
• Heavy drinking in the last 30 days
• At least 18 years of age
• Good general medical health (see Exclusion Criteria below)
• Capacity to provide informed consent
• English fluency and literacy

You may not qualify if…

• Psychiatric/behavioral: current post-traumatic stress disorder(PTSD); psychiatric disorder requiring any medication other than anti-depressants; currently taking disulfiram, acamprosate, or naltrexone or planning to take any of these medications during the 12-week medication phase of the study; current dependence on any other psychoactive substance other than nicotine or cannabis; a current diagnosis of opioid abuse, use of any opioid- containing medications or benzodiazepines during the previous month, or UDA positive for opioids, benzodiazepines, or sedative hypnotics.
• Medical: significant acute or chronic medical illness; women who are pregnant, nursing infant(s), or of childbearing potential and not using a contraceptive method judged by the study physician or PA to be effective; signs or symptoms of alcohol withdrawal at the time of initial consent
• Legal involvement that could interfere with study treatment. Individuals court ordered for treatment will not be eligible to participate in this study.

Where it is running

• VA Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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