Validation of an Assay to Measure Cyclooxygenase-1 Activity

Completed · Not applicable

Conditions studied: Healthy

In brief

The purpose of this study is to obtain a reference range for a newly developed assay of ex vivo platelet COX-1 activity in normal volunteers taking a routine clinical dose of aspirin.

Key facts

Study ID

NCT00761891

Run by

Vanderbilt University

People needed

64

Starts

2007-05-01

Expected to finish

2010-01-01

Last updated by the study team

2019-04-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Non-smoker
• No chronic medical illness
• No chronic medications

You may not qualify if…

• Aspirin/NSAID use in preceding 14 days
• History of chronic NSAID use
• Currently taking NSAIDs, opioid analgesics, corticosteroids, or anticoagulants
• History of coronary artery disease, myocardial infarction, coronary artery bypass grafting, percutaneous angioplasty, diabetes mellitus, or stroke.
• History of hypertension
• Body mass index > 35
• History of gastric, duodenal, or esophageal ulcers or serious gastrointestinal bleed
• History of frequent headaches, pain syndrome, or other condition requiring frequent use of analgesics
• History of adverse reactions to aspirin
• Screening platelet count < 100,000/ul or > 500,000/ul
• Screening hematocrit < 35% or > 50%
• Weight less than 110 pounds
• Pregnant females

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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