Cardiac Allograft Rejection Gene Expression Observational (CARGO) II STUDY

Completed

Conditions studied: Graft Rejection, Heart Disease

In brief

The Cardiac Allograft Rejection Gene Expression Observational (CARGO) II Study is designed to provide independent evidence of the clinical performance of the non-invasive AlloMap test. Sensitive detection of cardiac allograft rejection and dysfunction is the basis for successful recipient management. The CARGO II Study will assess the correlation between the presence or absence of acute cellular rejection as determined by examination of endomyocardial biopsy specimens with results from the AlloMap Test. Of 17 participating transplant centers, 4 are in North America and 13 are in Europe.

Key facts

Study ID

NCT00761787

Run by

XDx

People needed

800

Starts

2005-05-01

Expected to finish

2009-02-01

Last updated by the study team

2009-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• New and existing allograft recipients
• All patients (age ≥ 18years) receiving post-transplant care at the enrolling centers

You may not qualify if…

• Concurrent enrollment in a double-blind drug trial (immunosuppressive drugs).

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States
• Columbia University Medical Center — New York, New York, United States
• Texas Heart Institute — Houston, Texas, United States
• Medizinische Universität Innsbruck, Klinische Abteilung für Herzchirurgie — Anichstrasse 35, Innsbruck, Austria
• Medical University of Vienna (Medizinische Universität Wien) — Währinger Gürtel 18-20, State of Vienna, Austria
• UZ Gasthuisberg — Herestraat 49, Leuven, Belgium
• Toronto General Hospital — Toronto, Ontario, Canada
• Hospital La Pitie — 47 Bd de L, Paris, France
• Herz- und Diabeteszentrum NRW — Georgstraße 11, Bad Oeynhausen, Germany
• Medizinische Hochschule Hannover — Hanover, Carl-Neuberg-Str. 1, Germany
• UKM - Medizinische Klinik und Poliklinik C (Kardiologie und Angiologie) — Albert-Schweitzer-Str. 33, Münster, Germany
• Deutsches Herzzentrum Berlin — Augustenburger Platz, State of Berlin, Germany
• Ospedali Riuniti di Bergamo — Largo Barozzi 1, Bergamo, Italy
• Silesian Center for Heart Disease — Ul. Szpitalna 2, Zabrze, Poland
• Hospital Juan Canalejo — As Xubias 84, La Coruna, Spain
• Inselspital - Universitätsspital Bern Postfach 33 — Schweizer Herz-und Gefässzentrum Bern, Canton of Bern, Switzerland
• Papworth Hospital — Papworth Everard, Cambridge, United Kingdom

Full record on ClinicalTrials.gov

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