Methadone in Pediatric and Adult Sickle Cell Patients

Completed · Not applicable

Conditions studied: Sickle Cell Disease

In brief

To determine the pharmacokinetics of methadone in children and adults with SCD who are experiencing a painful episode.

Key facts

Study ID

NCT00761085

Run by

Washington University School of Medicine

People needed

47

Starts

2008-01-01

Expected to finish

2010-11-07

Last updated by the study team

2020-01-22

Who can join

Age: 7 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Greater than or equal to 7 years and less than or equal to 40 years
• Confirmed diagnosis of any form of sickle cell disease, including sickle cell anemia, sickle-hemoglobin C disease, and sickle-B thalassemia
• Currently experiencing a vaso-occlusive episode (VOE), defined as acute pain in the extremities
• Admitted to the inpatient unit for further treatment
• Started on morphine patient controlled analgesia and infusion for pain management

You may not qualify if…

• Diagnosis of acute chest syndrome
• New focal neurologic findings or clinical concern of stroke
• Aplastic crisis with hemoglobin 2 g/dl below steady-state value
• Allergy to morphine or methadone
• Any other medical condition that the attending physician deems to be a contraindication to therapy
• Liver or renal insufficiency or failure, and congestive heart failure

Where it is running

• Barnes Jewish Hospital/St. Louis Children's Hospital — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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