Remifentanil Propofol Infusion in Pediatric Spinal Surgery

Completed

Conditions studied: Spinal Fusion

In brief

Total intravenous anesthesia(TIVA) is a commonly used anesthetic technique. Although TIVA can be accomplished with a variety of drug combinations, infusions of Propofol and Remifentanil are often used with dosage adjusted manually by the anesthesia provider.The pharmacokinetics of these drugs are well understood, and that knowledge has led to the development of computer controlled infusion pumps that can administer the drugs based upon pharmacokinetic models. Computer controlled infusion schemes automatically adjust the drug administration based upon pharmacokinetic models which typically dictate a tapering infusion scheme. When one considers the dosage of a computer controlled infusion it is obvious that manually imitating a similar scheme may be difficult.This study will evaluate manually controlled infusion schemes using the models built into the Applied Medical Visualizations (Medvis) display and compare the manual dosage schemes to the predicted effect site concentrations and pharmacodynamic effect.

Key facts

Study ID

NCT00761072

Run by

Children's Hospital of Philadelphia

People needed

12

Starts

2008-07-01

Expected to finish

2009-04-01

Last updated by the study team

2013-03-07

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and Female patients age 0 to 18 years old
• Spinal surgery at CHOP between 4/1/07 and 3/31/08
• Complete CompuRecord Anesthesia documentation
• Use of Propofol and Remifentanil infusions as primary anesthetic technique

You may not qualify if…

• Chronic opioid or benzodiazepine medication use prior to surgery
• Use of other anesthetic infusions (i.e. Ketamine/Fentanyl) during TIVA
• Use of Neuraxial opioids
• Use of other Induction medications (i.e. Sodium Thiopental)

Where it is running

• The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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