Circulating Adenosine Levels Before and After Intravenous (IV) Persantine

Stopped early

Conditions studied: Ischemia, Coronary Disease

In brief

Persantine is a drug that is routinely used to determine blood flow to the heart in the diagnosis of coronary heart disease. Persantine causes an increase in the adenosine level in the blood. Adenosine is a naturally occurring substance in the body that can increase blood flow. Adenosine is normally removed from the bloodstream by an adenosine transporter, which is a protein that takes up adenosine from the blood into cells. The increase in adenosine levels in the blood is variable, and the cause for this variability is unknown. A mutation for this transporter gene may contribute to this variability, and may alter its function. Thus, the purpose of this study is to determine the relationship between the mutation and the transporter function.

Key facts

Study ID

NCT00760708

Run by

UConn Health

People needed

221

Starts

2005-09-01

Expected to finish

2011-12-01

Last updated by the study team

2019-05-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with or without coronary artery disease undergoing a Persantine nuclear stress test

You may not qualify if…

• Oral persantine use within 24 hours
• Second or third degree AV block, or sick sinus syndrome without a functioning pacemaker
• Active asthma or bronchospasm
• Those with end-stage liver disease such as cirrhosis or active hepatitis such as > 5 fold liver enzyme elevation will not be included
• Anemia (Hct < 30)
• Myocardial infarction within 30 days
• Severe left ventricular dysfunction (EF < 30%)

Where it is running

• University of Connecticut Health Center — Farmington, Connecticut, United States

Full record on ClinicalTrials.gov

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