The Role of Parathyroid Hormone (PTH) in Low Bone Mass in Anorexia Nervosa

Completed · Phase 2 · Has a placebo group

Conditions studied: Anorexia Nervosa, Osteoporosis

In brief

Decreased bone strength is a common and serious medical problem present in many women with anorexia nervosa, or disordered eating. Women with decreased bone strength are more likely to suffer broken bones than women with normal bone strength. We are investigating whether a hormone that is naturally produced by the human body -- parathyroid hormone (PTH) -- can help strengthen the bones of women with anorexia nervosa.

Key facts

Study ID

NCT00759772

Run by

Massachusetts General Hospital

People needed

23

Starts

2008-09-01

Expected to finish

2016-02-22

Last updated by the study team

2017-05-11

Who can join

Age: 30 and older, up to 70. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Anorexia Nervosa
• Women, age 30-70 years
• Osteoporosis or history of clinical fractures (spine, wrist, hip or ribs)

You may not qualify if…

• Diseases known to affect bone metabolism
• Hyperparathyroidism
• Medications known to affect bone metabolism in last 12 weeks (or bisphosphonate use in last 1 year)
• Pregnant and/or breastfeeding
• Diabetes mellitus
• History of malignancy involving or affecting the bone, any active malignancy, and/or radiation therapy to the bone
• Fractures of a bone other than a finger or toe in last 1 year

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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