D-Cycloserine Facilitation of Cocaine - Cue Extinction

Completed · Phase 2 · Has a placebo group

Conditions studied: Cocaine Use Disorders

In brief

The purpose of this study is to explore the use of d-cycloserine (DCS) to facilitate extinction of response to cocaine cues in cocaine-dependent individuals, in hopes that it may lead to the development of new treatment options for cocaine dependence.

Key facts

Study ID

NCT00759473

Run by

Medical University of South Carolina

People needed

79

Starts

2008-09-01

Expected to finish

2011-10-01

Last updated by the study team

2016-04-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.
• Subjects must meet DSM-IV criteria for current cocaine dependence. Subjects may meet criteria for abuse, but not dependence on any other substance with the exceptions of nicotine and alcohol. Because of the high comorbidity of cocaine with alcohol and nicotine dependence, excluding nicotine and alcohol dependence would seriously compromise the feasibility of recruitment. Nicotine use immediately prior to the cue exposure/extinction session will be controlled. Although individuals who meet criteria for alcohol dependence will be accepted for study participation, anyone who has a measurable blood alcohol level on the day of the sessions will be excluded as acute alcohol intake can increase serum levels of DCS and lower the seizure threshold.
• Use of one of the following methods of birth control by female subjects: birth control pills, barrier methods (diaphragm or condoms with spermicide or both), surgical sterilization, use of an intra-uterine contraceptive device, or complete abstinence from sexual intercourse.
• Subjects must live within a 50-mile radius of the research facility and have reliable transportation.
• Subjects must consent to remain abstinent from all drugs of abuse (except nicotine) prior to the first session and through the final session.
• Subjects must consent to random assignment to the DCS vs. placebo conditions.
• For fMRI participants, subjects must be right-handed.

You may not qualify if…

• Women who are pregnant, nursing or of childbearing potential and not practicing an effective means of birth control.
• Subjects with evidence of or a history of significant hematological, endocrine, cardiovascular, pulmonary, renal, gastrointestinal, or neurological disease including insulin-dependent diabetes, as these conditions may affect heart rate or skin conductance measurement.
• Subjects with a history of or current psychotic disorder, current major depressive disorder, bipolar affective disorder or a severe anxiety disorder as these may impact cue reactivity.
• Subjects who are unwilling or unable to maintain abstinence from alcohol and other drugs of abuse (except nicotine) prior to and between the cue procedures.
• Subjects meeting DSM-IV criteria for substance dependence (other than nicotine, alcohol or cocaine as appropriate) within the past 60 days.
• Subjects currently taking B-blockers, anti-arrhythmic agents, psychostimulants or any other agents known to interfere with heart rate and skin conductance monitoring.
• Known or suspected hypersensitivity to DCS.
• Individuals taking medications that could adversely interact with study medications, including, but not limited to ethionamide, isoniazid, or amino acid supplements.
• Subjects with a history of epilepsy or seizure disorder.
• Subjects with significant liver impairment, as DCS may increase serum transaminases.
• For fMRI participants, the need for maintenance or acute treatment with any psychoactive medication including anti-seizure medications which could potentially interfere with fMRI.
• For fMRI participants, clinically significant psychiatric or medical problems that would impair participation or limit ability to participate in scan.

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States
• Behavioral Health Services of Pickens County — Pickens, South Carolina, United States

Full record on ClinicalTrials.gov

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