Water as Therapy in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Completed · Not applicable

Conditions studied: Autosomal Dominant Polycystic Kidney Disease

In brief

Autosomal dominant polycystic kidney disease (ADPKD) is the most common single gene disorder that is potentially fatal. ADPKD is caused by mutations in either of two genes (PKD1, PKD2). Cysts begin to develop primarily in renal collecting tubules in utero and continue to form and expand throughout the patient's life. One of the goals of the study is to formulate a water prescription for use in clinical trials to determine the effect of sustained water diuresis on the progression of ADPKD.

Key facts

Study ID

NCT00759369

Run by

University of Kansas

People needed

11

Starts

2008-09-01

Expected to finish

2009-07-01

Last updated by the study team

2012-02-27

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ADPKD verified by ultrasound, CT or MRI, family history or physical exam
• Normal creatinine clearance, calculated by Cockroft-Gault formulat
• Good general health
• Controlled blood pressure, < 140/90
• Absence of urinary tract symptoms such as dysuria, hesitancy, diminished flow

You may not qualify if…

• Azotemia
• Uncontrolled hypertension
• Urinary tract symptoms, dysuria, hesitancy, diminished flow, gross hematuria
• Diabetes mellitus, cancer, hematologic disorder
• Unable to follow directions
• Solitary kidney
• History of CHF, liver dysfunction or hyponatremia
• Currently taking diuretics
• Nephrotic range proteinuria (3.5 g/day)

Where it is running

• University of Kansas Medical Center — Kansas City, Kansas, United States

Full record on ClinicalTrials.gov

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