Electroencephalography (EEG) Biomarkers of Response in Depression

Completed · Phase 4 · Has a placebo group

Conditions studied: Major Depressive Disorder

In brief

There are two specific aims of this project: 1. To identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cordance changes are specifically associated with response to venlafaxine 2. To identify predictors of placebo response in major depression using QEEG cordance/bispectral index (BIS) and neuropsychological testing

Key facts

Study ID

NCT00759122

Run by

University of California, Los Angeles

People needed

44

Starts

2002-11-01

Expected to finish

2005-12-01

Last updated by the study team

2008-09-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All subjects will meet DSM-IV criteria for depression on the basis of a SCID-P interview, with subjects having a score on the 17-item Ham-D > 17 (with item #1 > 2).
• Subjects will meet criteria both at recruitment and after a one-week single blind placebo wash-in. Study includes outpatients only.

You may not qualify if…

• All subjects will have no serious medical illness. The investigators will exclude patients also meeting criteria for the following groups of axis I diagnoses:
• delirium or dementia
• substance-related disorders
• schizophrenia or other psychotic disorders, or eating disorders.
• In addition, patients meeting criteria for cluster A or B axis II diagnoses will be excluded.
• Subjects with a history of current or past active suicidal ideation, or suicide attempts will be excluded from the study.

Where it is running

• UCLA Laboratory of Brain, Behavior, and Pharmacology — Los Angeles, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.