Using Rheological Methods to Characterize Cystic Fibrosis (CF) Sputum and the Effects of Mucoactive Agents

Completed

Conditions studied: Cystic Fibrosis

In brief

The purpose of this study is to characterize the rheological properties of cystic fibrosis (CF) and healthy sputum and to examine the effects of mucoactive agents on the rheology of CF and healthy sputum. By collaborating with Genentech, the investigators (scientists at UCSF) plan to incorporate the latest scientific findings into our work to discover and develop new treatments for CF.

Key facts

Study ID

NCT00758771

Run by

University of California, San Francisco

People needed

38

Starts

2007-10-01

Expected to finish

2012-12-01

Last updated by the study team

2014-03-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy control subjects:
• Age 18-65
• No history of lung disease or cardiac disease
• Cystic fibrosis subjects:
• Age 18-65
• Diagnosis of CF - sweat chloride values > 60 mM on pilocarpine iontophoresis sweat tests and/or 2 allelic CF-producing mutations by genetic analysis

You may not qualify if…

• Use of recreational drugs within 1 year prior to enrollment
• Use of tobacco within 1 year prior to enrollment, or > 10 pack-year tobacco history
• Upper respiratory tract infection in the 4 weeks prior to enrollment in the study
• Current use of antihistamines to treat allergies

Where it is running

• UCSF Airway Clinical Research Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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