Frontline Treatment With Bendamustine in Combination With Rituximab in Adults Age 65 or Older With Chronic Lymphocytic Leukemia (CLL)

Withdrawn before enrolling · Phase 2

Conditions studied: Chronic Lymphocytic Leukemia

In brief

Many chemotherapy combinations may be used to treat patients with chronic lymphocytic leukemia (CLL). Although there are many options, a single, best option is not agreed upon by most cancer specialists. Bendamustine, a medicine recently approved for use in the United States, has been used in combination with rituximab in previous studies to treat patients whose CLL has returned after previous standard treatments. The purpose of this study is to determine whether bendamustine with rituximab is effective for the initial treatment of CLL for patients aged 65 and older.

Key facts

Study ID: NCT00758693
Run by: University of Kentucky
People needed: 0
Starts: 2008-10-01
Expected to finish: 2010-07-01
Last updated by the study team: 2012-01-11

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients must have histologically or cytologically confirmed chronic lymphocytic leukemia.
A minimum of any one of the following disease-related symptoms must be present:
Weight loss ≥10% within the previous 6 months.
Extreme fatigue (ie, ECOG PS 2; cannot work or unable to perform usual activities).
Fevers of greater than 100.5"F for ≥ 2 weeks without evidence of infection.
Night sweats without evidence of infection. or
Evidence of progressive marrow failure as manifested by the development of, or worsening of, anemia and/or thrombocytopenia or
Autoimmune anemia and/or thrombocytopenia poorly responsive to corticosteroid therapy or
Massive (ie, >6 cm below the left costal margin) or progressive splenomegaly or
Massive nodes or clusters (ie, > 10 cm in longest diameter) or progressive lymphadenopathy or
Progressive lymphocytosis with an increase of >50% over a 2-month period, or an anticipated doubling time of less than 6 months but
Marked hypogammaglobulinemia or the development of a monoclonal protein in the absence of any of the above criteria for active disease is not sufficient for protocol therapy
No prior therapy for CLL is allowed. Participants may have taken corticosteroids previously but must be ≥ 28 days from last dose prior to enrolment.
Age >65 years.
Life expectancy of greater than 1 year.
ECOG performance status better than or equal 2.
Patients must have normal organ and marrow function as defined below:
total bilirubin within normal institutional limits unless resulting from documented hemolysis
AST(SGOT)/ALT(SGPT) <2.5 X institutional upper limit of normal
creatinine within normal institutional limits OR
creatinine clearance >60 mL/min/1.73 m2 for patients with creatinine levels above institutional normal
Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

Patients who have had previous chemotherapy or radiotherapy for the treatment of CLL.
Patients may not be receiving any other investigational agents.
Patients with known brain involvement should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
History of allergic reactions attributed to compounds of similar chemical or biologic composition to bendamustine or rituximab.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
HIV-positive patients are ineligible because these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy.
Patients with a known history of viral hepatitis, with the exception of Hepatitis A that has recovered.
Patients who require concomitant treatment with CYP1A2 inhibitors including: Cimetidine, Ciprofloxacin, Fluvoxamine, Ticlopidine.

Where it is running

University of Kentucky — Lexington, Kentucky, United States

Full record on ClinicalTrials.gov

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