Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction
Completed · Phase 2
Conditions studied: Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
In brief
RATIONALE: Monoclonal antibodies, such as panitumumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to kill tumor cells or stop them from growing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy together with panitumumab and radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This phase II trial is studying how well giving panitumumab together with docetaxel, cisplatin, radiation therapy, and surgery works in treating patients with newly diagnosed, locally advanced esophageal cancer or cancer of the gastroesophageal junction.
Key facts
- Study ID
- NCT00757172
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 70
- Starts
- 2009-01-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2016-03-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
- University of Chicago Cancer Research Center — Chicago, Illinois, United States
- Evanston Hospital — Evanston, Illinois, United States
- Simmons Cooper Cancer Institute — Springfield, Illinois, United States
- Central Baptist Hospital — Lexington, Kentucky, United States
- William Beaumont Hospital - Royal Oak Campus — Royal Oak, Michigan, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
- Blumenthal Cancer Center at Carolinas Medical Center — Charlotte, North Carolina, United States
- Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
- Good Samaritan Hospital — Dayton, Ohio, United States
- Wayne Hospital — Greenville, Ohio, United States
- Charles F. Kettering Memorial Hospital — Kettering, Ohio, United States
- Providence Cancer Center at Providence Portland Medical Center — Portland, Oregon, United States
- Legacy Emanuel Hospital and Health Center and Children's Hospital — Portland, Oregon, United States
- Geisinger Cancer Institute at Geisinger Health — Danville, Pennsylvania, United States
- Allegheny Cancer Center at Allegheny General Hospital — Pittsburgh, Pennsylvania, United States
- UPMC Cancer Centers — Pittsburgh, Pennsylvania, United States
- Hollings Cancer Center at Medical University of South Carolina — Charleston, South Carolina, United States
Full record on ClinicalTrials.gov
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