Biomarkers and Genetic Factors Related to Emphysema

Completed

Conditions studied: Emphysema, Pulmonary Disease, Chronic Obstructive

In brief

Emphysema, a common type of chronic obstructive pulmonary disease (COPD), is a long-term lung disease that is usually caused by cigarette smoking. This study will examine both current smokers and former smokers who have emphysema, as well as current and former smokers who do not have emphysema, to determine if certain factors found in the blood are related to the risk of developing emphysema.

Key facts

Study ID

NCT00757120

Run by

Washington University School of Medicine

People needed

145

Starts

2007-10-01

Expected to finish

2011-09-01

Last updated by the study team

2018-05-04

Who can join

Age: 45 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Pregnant
• Prisoner
• Vulnerable populations
• Recent illness (defined as increased cough, sputum production, worsening malaise, or need for unscheduled physician visit in the 6 weeks prior to enrollment)
• Coexisting active chronic inflammatory or collagen vascular disease, immunodeficiency of any kind, non-cutaneous malignancy (melanoma is an exclusion), or previous organ transplant
• Congenital abnormalities of the lung or previous lung surgery
• Known active hepatitis B, hepatitis C, or HIV/AIDS (not prospectively evaluated)
• CT evidence of lung disease other than emphysema (including significant fibrosis, bronchiectasis, consolidation, or indeterminate nodules)

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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