Lowering Serum Uric Acid to Prevent Acute Kidney Injury

Completed · Phase 2 · Has a placebo group

Conditions studied: Hyperuricemia

In brief

Acute kidney injury is associated with a rise in serum uric acid during cardiovascular surgery and can cause poor blood flow to the kidneys making them vulnerable to kidney injury. We hypothesize that hyperuricemia, particularly if chronic and marked, is a risk factor for acute kidney injury. The preoperative lowering of serum uric acid will reduce the incidence of acute kidney injury following cardiovascular surgery.

Key facts

Study ID

NCT00756964

Run by

University of Florida

People needed

26

Starts

2008-10-01

Expected to finish

2011-08-01

Last updated by the study team

2012-09-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older, and
• Undergoing elective cardiothoracic surgery(s), alone or in combination with other procedures/surgery(s): thoracic aortic aneurysm, cardiac valves, coronary artery bypass grafting, abdominal thoracic aneurysm, other CV surgery, and
• Preoperative serum uric acid > 6.5 mg/dL, and
• Preoperative estimated glomerular filtration rate of >30ml/min/1.73m2 or higher, but less than 60ml/min/1.73m2

You may not qualify if…

• Prior history of allergy/adverse reaction to Rasburicase
• History of any organ transplant
• Preoperative intra-aortic balloon pump (IABP)
• Known glucose 6-phosphate dehydrogenase (G6PD) deficiency
• Current use of natriuretic peptides

Where it is running

• University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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