Vitamin D Deficiency and Low Bone Mineral Content in Children

Completed

Conditions studied: Vitamin D Deficiency, Obesity

In brief

The Vitamin D study is designed to investigate the effect of body fat mass on vitamin D levels in children. Earlier studies have shown that individuals with increased fat mass may have low vitamin D levels. Our specific hypothesis states that children with increased fat mass will have lower blood levels of vitamin D when compared to non-obese children.Since vitamin D is the primary hormone for bone mineralization in humans, low levels of vitamin D could lead to decreased bone mineral content in these children.

Key facts

Study ID

NCT00756899

Run by

University of Massachusetts, Worcester

People needed

45

Starts

2008-07-01

Expected to finish

2012-05-01

Last updated by the study team

2012-10-26

Who can join

Age: 3 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• General: Prepubertal children (males, with testicular volume of ≤ 3 cc, and girls with Tanner 1 breast) of ages 7-11 years will be enrolled in the study.
• Study group: Subjects with a BMI of > 95th percentile for age and sex.
• Control group: All control subjects will have a BMI of < 85th percentile for age and sex.

You may not qualify if…

• known metabolic or genetic diseases resulting in obesity such as severe hypothyroidism, pseudohypoparathyroidism, or Cushing's disease
• diabetes mellitus
• subjects on lipid lowering medications
• subjects on medications known to impact body weight or calcium homeostasis
• subjects with a history of recent significant weight loss or gain

Where it is running

• University of Massachusetts Medical School — Worcester, Massachusetts, United States

Full record on ClinicalTrials.gov

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