Analyzing Lung Tissue in People With and Without Chronic Obstructive Pulmonary Disease Who Are Undergoing Lung Transplantation
Completed
Conditions studied: Pulmonary Disease, Chronic Obstructive
In brief
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease. People with COPD have difficulty breathing because of lung damage. However, for many people with COPD, while some areas of the lungs are damaged, other nearby areas are not. This study will examine lung tissue from people with and without COPD who are undergoing lung transplantation to investigate how and why certain areas of the lungs are damaged in some people but not others.
Key facts
- Study ID
- NCT00756522
- Run by
- Washington University School of Medicine
- People needed
- 63
- Starts
- 2007-10-01
- Expected to finish
- 2016-05-01
- Last updated by the study team
- 2018-06-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age equal to or greater than 18 years
- Ability to read and write in English
- Able to participate in the informed consent process
- Listed at Barnes-Jewish Hospital for lung transplantation for COPD (with alpha-1-antitrypsin deficiency [A1ATD] or non-1ATD)
- Global Initiative for Chronic Obstructive Lung Disease (GOLD) class IV COPD
- Acceptable chest computed tomography (CT) exam completed at Barnes-Jewish Hospital in the 3 years before study entry
You may not qualify if…
- Pregnant
- Prisoner
- Vulnerable populations
- Coexisting active chronic inflammatory or collagen vascular disease, immunodeficiency of any kind, non-cutaneous malignancy (melanoma is an exclusion), or previous organ transplant
- Coexisting (other than COPD / emphysema / chronic bronchitis)significant pulmonary parenchymal disorder (e.g., pulmonary fibrosis)
- Exclusion Criteria for 3-Helium MRI Procedure:
- Inability to perform 10 to 15 second breath hold for 3-Helium MRI scan.
- Contraindications to MRI (including pacemaker, metal implants, other devices affected by the magnet).
- Contraindications to 3-Helium MRI (including significant anemia [hemoglobin less than or equal to 12 g/dL, with the last testing within 1 month of the MRI scan] or marked oxyhemoglobin desaturation at rest when breathing room air [requiring more than 4 liters per minute of supplemental oxygen to keep saturation of oxygen (SaO2) at least 90%]).However, patients deemed to be low risk kfor complications of cerebrovascular disease, cardiovascular disease, heart dysrhythmias, and seizures through the thorough lung transplant evaluation will be eligible for testing. Since most of the patients with these contraindications to 3-Helium MRI will be ineligible for lung transplantation, we expect few patients to have such contraindications to testing.
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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