Post-conditioning to Reduce Infarct Size

Completed · Not applicable

Conditions studied: Myocardial Infarction

In brief

When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels. This is called "reperfusion injury". The cell death is due to inflammation and the generation of free radicals. The primary objective of this study is to determine if post-conditioning(four brief (30 second) PTCA balloon inflations) reduces damage to the heart muscle. This will be measured by heart enzyme tests-CK measurements- and by cardiac MRI.

Key facts

Study ID

NCT00755469

Run by

Minneapolis Heart Institute Foundation

People needed

43

Starts

2008-09-01

Expected to finish

2010-08-01

Last updated by the study team

2013-12-05

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 < 80
• Able to give informed consent
• 100% occlusion of a major epicardial vessel with TIMI 0 Flow

You may not qualify if…

• Significant collateral blood flow to the distal vasculature of the occluded vessel.
• Previous CABG
• Previous q-wave myocardial infarction in the same territory

Where it is running

• Abbott Northwestern Hospital — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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