Total Knee Arthroplasty And Thromboembolism: A Comparison Between Two Surgical Techniques

Completed

Conditions studied: Total Knee Replacement, Venous Thromboembolism

In brief

In patients undergoing total knee arthroplasty, thromboembolism is a common occurrence, especially following tourniquet deflation. The resulting cardiopulmonary emboli can potentially lead to hypoxemia, hypotension, hemodynamic collapse and post operative cognitive dysfunction due to emboli. The standard surgical technique involves placing an intramedullary rod in the femur to determine the angle and degree of resection from the end of the femur. A new surgical technique utilizes computer navigation system to perform the desired cuts in the appropriate position. The investigators hypothesize that the avoidance of intramedullary instrumentation in computer assisted total knee replacement will result in fewer thromboembolic events compared with the standard technique using manual instrumentation in the femur. The present study will test this hypothesis by quantifying the extent of thromboembolism during both surgical techniques.

Key facts

Study ID

NCT00755300

Run by

University of California, Davis

People needed

15

Starts

2006-06-01

Expected to finish

2009-06-01

Last updated by the study team

2011-08-15

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients scheduled to undergo Total Knee Arthroplasty at UC Davis Medical Center
• 18 years and above

You may not qualify if…

• Any contraindication to perform TEE

Where it is running

• University of California, Davis Medical Center — Sacramento, California, United States

Full record on ClinicalTrials.gov

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