The Effects of Epinephrine in Endotoxemia in Normal Volunteers

Completed · Phase 1

Conditions studied: Immune System

In brief

Epinephrine (adrenaline) is a substance produced by the body (in the adrenal gland) in response to stress such as infection or injury. Endotoxin is a man- made substance, which causes the body to "mimic" sickness (fever, chills, and achiness) for a few hours. This study is designed to give epinephrine before and/or after endotoxin to determine if this medication can prevent or relieve any of the symptoms caused by endotoxin.

Key facts

Study ID

NCT00753402

Run by

Rutgers, The State University of New Jersey

People needed

37

Starts

2012-02-01

Expected to finish

2012-02-01

Last updated by the study team

2015-05-27

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• General good health as demonstrated by medical history, physical\& laboratory tests
• Age between 18 and 40 years
• Written informed consent prior to the performance of any study related procedures

You may not qualify if…

• History of cancer, rheumatoid arthritis, or immunological, renal, hepatic, endocrine, neurologic, heart disease or hypertension
• Any medication taken in past 48 hrs (except birth control)
• Recent history of alcohol or drug abuse
• Unable to provide written informed consent
• Exposure to any experimental agent or procedure within 30 days of study
• Pregnant or breast-feeding

Where it is running

• Rutgers-RWJMS — New Brunswick, New Jersey, United States

Full record on ClinicalTrials.gov

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