AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy

Stopped early

Conditions studied: Osteoarthritis

In brief

The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.

Key facts

Study ID

NCT00752271

Run by

National Institute on Aging (NIA)

People needed

32

Starts

2008-05-01

Expected to finish

2010-05-01

Last updated by the study team

2009-12-18

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 40 or older
• Potential candidate for knee arthroscopy for medial
• Meniscal tear confirmed on MRI
• Prior meniscal resection at least 1 year prior with a persistent knee effusion
• Body mass index between 25-35 kg/m2

You may not qualify if…

• Knee injury in the 1 month before the initial study evaluation
• Knee surgery within 1 year before the initial study evaluation
• Pace-maker or defibrillator, 2nd or 3rd degree heart block, or other abnormal rhythms
• Current diagnosis of diabetes mellitus, a fasting glucose>100mg/dl or >140 mg/dl 2 hour after a glucose challenge
• Current diagnosis of an inflammatory condition (e.g. rheumatoid arthritis, gout, etc)
• Untreated thyroid disease
• Morbid obesity (body mass index >35)
• Neuropathy or nerve damage
• Stroke or transient-ischemic attacks (mini-stroke)
• Recent diagnosis of congestive heart failure or heart attack
• Use of prednisone or chemotherapy, steroid or other joint or ant-inflammatory agents in the past 3 months
• Current use of medications that influence heart rate
• Cognitive impairment that limits your ability to provide informed consent
• Pregnancy

Where it is running

• NIA Clinical Research Unit — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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