Safety Study of Lopinavir/Ritonavir With Raltegravir in HIV-infected Patients

Completed · Phase 4

Conditions studied: HIV Infections

In brief

A single center, open label, 48-week study of lopinavir/ritonavir in combination with raltegravir. 30 patients, both naïve and experienced, will be enrolled. 15 treatment naïve patients and 15 treatment experienced patients enrolled

Key facts

Study ID: NCT00752037
Run by: Saint Michael's Medical Center
People needed: 30
Starts: 2008-09-01
Expected to finish: 2010-06-01
Last updated by the study team: 2011-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

HIV-1 infection, as documented by any licensed ELISA test kit, and confirmed by Western blot, positive HIV-1 blood culture, positive HIV serum antigen, or plasma viremia at any time prior to study entry. If no record exists, testing must occur at screening.
Males and non-pregnant females > 18 years of age. (Children are being excluded as they are immunologically different than adults)
HIV-1 RNA > 1000 copies/ml for both patient naive and experienced to antiretroviral therapy in order for phenotypic susceptibility to be performed. There in no inclusion criteria for CD4 count.
Treatment experienced patients , defined as having taken medications from two of the following three classes of antiretrovirals: NRTI, NNRTI, or PI must have phenotypic susceptability to lopinavir/ritonavir as resulted by Phenosense GT
Laboratory tests ( Cbc w/diff, comprehensive metabolic panel) within pre-specified limits
Able to sign the informed consent, and is willing to comply with the requirements of this clinical trial.
Available for at least 52 weeks of follow up
If female and of child bearing potential must consent to remain abstinent throughout the study period and for 30 days after the last dose of study medications.( this is standard language)

You may not qualify if…

Pregnant or breast-feeding woman (pregnant women are being excluded as drug kinetics are different in pregnancy and the dynamics of immune reconstitution are unknown in this group)
Current treatment for malignancy other than basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix or isolated cutaneous Kaposi's Sarcoma that is not being treated; those with prior cancer diagnosis, such as lymphomas must have been disease-free for at least 5 years
Absolute neutrophil count < 500, platelet count < 50,000, hemoglobin < 8 gm/dL
Evidence of end-organ disease, defined as follows: renal (calculated creatinine clearance of less than 50 mL/min); liver (liver-associated enzymes > 3 times the upper limits of normal)
Grade 3 (ACTG Grading Scale) or higher cholesterol or triglyceride elevations
Acute, serious infection requiring prescription drug therapy within 30 days prior to study entry
In the opinion of the investigator, there is evidence of an active ongoing opportunistic infection
Must not currently be undergoing treatment for an opportunistic infection.
Use of immune stimulation agents known to impact CD4 cell count in the peripheral circulation, to include IL2, interferon, G-CSF, GM-CSF, etc.
Use of immune suppressant drugs, with the exception of < 10 mg/day of prednisone .
Unwillingness to remain abstinent for duration of study
Experimental vaccines, to include HIV vaccines.
Patient who is currently enrolled in an experimental protocol, or is receiving an experimental medication.
Patients on 2 NRTIs with an NNRTI and a PI combination will not be allowed in the study.

Where it is running

Saint Michael's Medical Center — Newark, New Jersey, United States

Full record on ClinicalTrials.gov

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