Cerebral and Peripheral Perfusion Pilot Study

Completed · Phase 2 · Has a placebo group

Conditions studied: Alzheimer's Disease

In brief

The purpose of this study is to evaluate the hypothesis that in middle-aged, asymptomatic, adult children of persons with Alzheimer's disease (AD), atorvastatin therapy will beneficially affect mechanisms thought to contribute to AD risk by improving blood flow in the brain, improving cerebral perfusion, increasing brain activity patterns, and improving blood vessel function.

Key facts

Study ID

NCT00751907

Run by

University of Wisconsin, Madison

People needed

16

Starts

2006-06-01

Expected to finish

2007-04-01

Last updated by the study team

2019-09-09

Who can join

Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult (ages 40-65) children of parent with documented Alzheimer's disease

You may not qualify if…

• Current use of cholesterol lowering medication
• History of liver disease
• History of adverse reaction to statin medications
• Elevated lab values (CK and creatinine)
• Use of medications that counteract with atorvastatin
• History of dementia
• Currently pregnant
• Use of large quantities of grapefruit juice (more than 1 quart/day)
• Current involvement in another investigational drug study
• Contraindications to MRI

Where it is running

• Karen Lazar — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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