Cortisol Augmentation of Prolonged Exposure Therapy

Completed · Not applicable · Has a placebo group

Conditions studied: PTSD

In brief

This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the treatment of posttraumatic stress disorder (PTSD). The augmentation builds on both the translation of neuroscience findings demonstrating the effects of glucocorticoids (GCs) on learning, and on empirical clinical findings from other investigators demonstrating beneficial effects of GCs in reducing traumatic memories in trauma-exposed persons.

Key facts

Study ID

NCT00751855

Run by

VISN 3 Mental Illness Research, Education and Clinical Center

People needed

11

Starts

2008-07-01

Expected to finish

2011-02-01

Last updated by the study team

2012-07-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans who experienced a criterion A trauma while deployed, and a current diagnosis of PTSD with a minimum of 6 months
• Capable of understanding, reading and writing English

You may not qualify if…

• Incapable and/or unwilling to provide written informed consent prior to participation
• Unwilling and/or unable to discontinue current psychotherapy
• Regular use of psychotropic medication including antidepressants, benzodiazepines, lithium, mood stabilizers, over-the-counter supplements (melatonin, kava-kava, ephedra)
• Regular use of oral or inhaled steroids
• Significant illness (e.g., type I or II diabetes requiring the use of insulin, HIV, AIDS, seizure disorder, anemia, Lyme disease, etc.)
• The veteran, the veteran's physician, or the study physician think that the veteran's clinical state necessitates the prompt initiation of pharmacotherapy or other treatment that would preclude involvement in the study
• Morbid obesity (VMI > 40)
• Clinically significant laboratory abnormalities as determine during medical clearance procedures
• For women, a positive pregnancy test
• Heavy smoking (more than 2 packs a day)
• Substance and/or alcohol abuse and/or dependence within the previous 6 months
• Response of 3 or 4 on the suicidality items of the HDRS or an assessed serious suicide risk
• Current psychosocial problems that might interfere with treatment compliance
• A lifetime history of schizophrenia, schizoaffective disorder, bipolar disorder, obsessive compulsive disorder or PTSD due to a trauma not sustained in the combat theater

Where it is running

• James J. Peters Veterans Affairs Medical Center — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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