Lung Allograft Rejection Gene Expression Observational (LARGO) Study

Stopped early

Conditions studied: Graft Rejection, Lung Disease

In brief

The objective of the LARGO Study protocol is to collect peripheral blood samples, select associated lung biopsy pathology slides, and clinical data from lung transplant recipients to perform molecular analyses in association with the study endpoints. The primary objective is to use gene expression profiling of peripheral blood mononuclear cells to differentiate between the absence and presence of acute cellular rejection. The secondary objectives are to use other genomic and proteomic technologies to analyze RNA and protein in blood samples in relation to related clinical conditions. The overall goal is to apply novel molecular insights in the development of non-invasive molecular diagnostic tests for lung transplantation.

Key facts

Study ID

NCT00751309

Run by

XDx

People needed

2044

Starts

2004-04-01

Expected to finish

2009-01-01

Last updated by the study team

2008-12-18

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Lung and heart-lung transplant recipients who consent to participate and have transbronchial biopsy at the enrolling center during the study period

You may not qualify if…

• None

Where it is running

• UCLA Division of Pulmonary and Critical Care — Los Angeles, California, United States
• University of California, San Francisco — San Francisco, California, United States
• Stanford University School of Medicine — Stanford, California, United States
• University of Colorado — Aurora, Colorado, United States
• Mayo Clinic Transplant Center — Jacksonville, Florida, United States
• University of Michigan Health Systems — Ann Arbor, Michigan, United States
• St. Louis Children's Hospital — St Louis, Missouri, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Columbia University College of Physicians and Surgeons — New York, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• The Cleveland Clinic — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• University of Washington Medical Center — Seattle, Washington, United States
• University Hospital and Clinics — Madison, Wisconsin, United States
• Medizinische Universität Wien — Vienna, Austria
• Hospital for Sick Children — Toronto, Ontario, Canada
• Toronto General Hospital — Toronto, Ontario, Canada
• Medizinische Hochschule Hannover — Hanover, Germany
• Freeman Hospital — High Heaton, Newcastle upon Tyne, United Kingdom

Full record on ClinicalTrials.gov

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