Slope of the Pressure-Time Waveform Predicts Resistance and Compliance in Mechanically Ventilated Subjects
Completed
Conditions studied: Respiration Disorders
In brief
There are two fundamentally different ways to ventilate critically ill patients: constant flow, volume-preset modes (such as volume assist-control) and pressure-preset modes (such as pressure-control and pressure-support). Critically ill patients suffer mechanical derangements of the respiratory system that raise the work of breathing. Knowledge of these mechanical properties is useful diagnostically and as a measure of response to treatment over time. It has been proposed that only constant flow, volume-preset modes are able to offer diagnostic information about the changes in the subject's lungs in terms of resistance and elastance properties. This study proposes to examine if similar information can be extracted from pressure-preset modes by comparing information from both modes of ventilation.
Key facts
- Study ID
- NCT00750074
- Run by
- Gregory A. Schmidt
- People needed
- 12
- Starts
- 2007-11-01
- Expected to finish
- 2010-10-01
- Last updated by the study team
- 2017-02-28
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects may be included in the study if they meet the following inclusion criterion and no exclusion criteria:
- Adult medical or surgical ICU patients who are mechanically ventilated.
You may not qualify if…
- Subjects with planned extubation at time of screening
- Subjects who are judged too hemodynamically unstable by their attending physician to participate in the study
- Subjects on high-frequency ventilation
- Subjects whose oxyhemoglobin saturation cannot be maintained at 88% or greater
- Subjects with large air leaks around the endotracheal or tracheostomy tube
- Subjects younger than 18 years old
- Inability to obtain informed consent from the subject or the subject's authorized representative
Where it is running
- Univesity of Iowa — Iowa City, Iowa, United States
Full record on ClinicalTrials.gov
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