Cognitive Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder

Completed · Not applicable

Conditions studied: Obsessive-Compulsive Disorder

In brief

This study will examine the way cognitive behavioral therapy changes the structure of the brain in patients with obsessive-compulsive disorder and will thereby determine what makes cognitive behavioral therapy an effective treatment.

Key facts

Study ID

NCT00748761

Run by

University of California, Los Angeles

People needed

119

Starts

2008-06-01

Expected to finish

2016-12-31

Last updated by the study team

2020-03-25

Who can join

Age: 6 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Meets DSM-IV diagnostic criteria for OCD as primary diagnosis, based on the Anxiety Disorders Interview Schedule (ADIS) Clinical Severity Rating
• Clinical Global Impressions severity score of at least 4, reflecting moderately ill or worse status
• Children's Yale-Brown Obsessive Compulsive Scale total score of greater than or equal to 16
• No medication for OCD or other psychiatric condition in the past 4 weeks and no use of fluoxetine for the past 6 weeks
• Child is fluent in English
• Parental informed consent and child or adolescent informed assent forms are signed
• For females of childbearing potential a negative pregnancy test will be required for study entry

You may not qualify if…

• IQ of less than 80 on the Wechsler Abbreviated Scales of Intelligence
• A lifetime DSM-IV diagnosis of pervasive developmental disorder, mania, psychosis, conduct disorder, or substance dependence assessed through ADIS
• Current DSM-IV diagnosis of major depressive disorder or attention deficit hyperactivity disorder any subtype, assessed through an ADIS rating of 4 or higher
• Any serious psychiatric, psychosocial, or neurological condition, such as a tic disorder, non-OCD anxiety, aggression, or family discord, that requires immediate treatment other than that provided in the current study
• One or more failed adequate trials of exposure-based CBT, defined as at least 10 sessions of therapist-assisted, exposure-based CBT with which the patient voluntarily complied
• More than one failed selective serotonin reuptake inhibitor trial adequate in dose and duration, defined as at least 8 weeks of treatment with at least 20 mg of fluoxetine, 20 mg of paroxetine, 75 mg of sertraline or fluvoxamine, or 75mg of clomipramine
• Any body metal (other than dental fillings), pregnancy, or other contraindications to MRSI scan

Where it is running

• UCLA Child Psychiatry — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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