Dopamine in Orthostatic Tolerance

Stopped early · Not applicable

Conditions studied: Postural Tachycardia Syndrome

In brief

One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will also study whether increasing dietary salt improves symptoms during upright posture. Finally, we will examine whether the dietary sodium level influences serum DBH activity and whether DBH level influences the response to sodium. DBH levels and the function of the sympathetic or involuntary nervous system will be assessed in normal volunteers and in patients with postural tachycardia syndrome (POTS).

Key facts

Study ID

NCT00748228

Run by

Vanderbilt University

People needed

22

Starts

2004-11-01

Expected to finish

2012-07-01

Last updated by the study team

2015-06-15

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Upright plasma norepinephrine > 600 pg/ml, or
• An increase in heart rate of > 30 beats per minute upon standing, and
• Withdrawal of all medications for at least 3 days, and
• No associated medical illness, and
• Age 18 - 60 years old.

You may not qualify if…

• Older than 60 years of age
• Routinely taking medications affecting the autonomic nervous system
• Any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic) other than POTS
• Anemia (Hct < 30)
• Women of childbearing age who are pregnant or nursing
• Unable to give informed consent

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.