The Pathophysiology of Orthostatic Hypotension

Completed · Phase 1 · Has a placebo group

Conditions studied: Autonomic Nervous System Diseases, Orthostatic Hypotension, Dopamine Beta-Hydroxylase Deficiency, Orthostatic Intolerance

In brief

The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.

Key facts

Study ID

NCT00748059

Run by

Vanderbilt University Medical Center

People needed

10

Starts

1996-12-01

Expected to finish

2020-12-01

Last updated by the study team

2021-05-12

Who can join

Age: 12 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• severe orthostatic hypotension and other autonomic symptoms but do not meet criteria for standard diagnosis
• non-smokers
• drug-free
• able to give informed consent
• free of pulmonary, renal, hematopoietic, hepatic and cardiac disease

You may not qualify if…

• medications affecting the autonomic nervous system
• any chronic illness
• anemia (Hct<30)
• women of childbearing age who are pregnant or nursing
• smokers

Where it is running

• Vanderbilt University — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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