TSH Receptor Mutations Among a Consanguineous Community

Completed

Conditions studied: Hypothyroidism

In brief

Resistance to thyrotropin (RTSH) is a condition of impaired responsiveness of the thyroid gland to TSH, characterized by elevated TSH, low or normal thyroid hormone levels, and hypoplastic or normal-sized thyroid gland. The aim of the present study was to evaluate the clinical course over time,the genotype-phenotype association and the frequency of two different TSH-receptor (TSHR) mutations in a highly consanguineous population of the town of Um-El-Fahem.

Key facts

Study ID

NCT00747760

Run by

HaEmek Medical Center, Israel

People needed

209

Starts

2005-12-01

Expected to finish

2006-12-01

Last updated by the study team

2008-09-11

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects belonging to extended family of the index case

Where it is running

• Samuell Refetoff — Chicago, Illinois, United States
• Ha'Emek Medical Center — Afula, Israel

Full record on ClinicalTrials.gov

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