Platelet-activating Factor Acetylhydrolase (Paf-ah) Gene Expression

Completed

Conditions studied: Low Birth Weight Infant

In brief

This is a prospective observational study to determine whether there is an association between the presence of platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphisms and the development of chronic lung disease in very low birth wight infants. Infants \< 1500 grams at birth who require mechanical ventilation will be enrolled in the first 5 days of life after obtaining informed consent. A total of 1 ml of blood will be drawn and utilized for isolation of DNA for genotyping and for measurement of PAF-AH activity in serum.

Key facts

Study ID

NCT00747240

Run by

University of Utah

People needed

139

Starts

2002-02-01

Expected to finish

2014-12-01

Last updated by the study team

2015-05-12

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients hospitalized in the NICU who:
• weigh ≤ 1500 grams at birth,
• are enrolled at age ≤ 5 days,
• require mechanical ventilation or continuous positive airway pressure (CPAP),
• have parents or guardians that have signed the informed consent document.

You may not qualify if…

• Infants with major congenital anomalies will be excluded.

Where it is running

• University of Utah — Salt Lake City, Utah, United States
• Primary Children's Medical Center — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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