Airway Epithelium Gene Expression: AEGIS IDE

Completed

Conditions studied: Lung Cancer

In brief

The purpose of the research study is to develop a new, more sensitive, and less invasive test for diagnosing lung cancer at an earlier stage, when it can more easily be cured. The investigators hypothesize that certain genes are expressed differently in current and former smokers who have lung cancer, and this difference in gene expression may be a biomarker for lung cancer.

Key facts

Study ID

NCT00746759

Run by

Allegro Diagnostics, Corp.

People needed

1331

Starts

2010-02-01

Expected to finish

2015-02-01

Last updated by the study team

2015-06-04

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients being evaluated for the diagnosis of possible lung cancer or "rule out lung cancer" and undergoing clinically indicated bronchoscopy
• All patients are required to be at least 21 years of age and be able to understand and sign the informed consent form
• Patient must be a current or former cigarette smoker

You may not qualify if…

• A pulmonary physician does not recommend that bronchoscopy be performed
• Inability to understand the written consent form and comply with requirements of the study
• History of prior primary lung cancer
• Immediately prior to bronchoscopy, the patient has been on a mechanical ventilator for >24 consecutive hours.

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• Pulmonary Associates of Arizona — Phoenix, Arizona, United States
• University of California- Davis — Sacramento, California, United States
• National Jewish Health — Denver, Colorado, United States
• Yale Univeristy — New Haven, Connecticut, United States
• North Florida/South Georgia VA — Gainesville, Florida, United States
• Indiana University — Indianapolis, Indiana, United States
• LSU — New Orleans, Louisiana, United States
• St. Elizabeth's Medical Center — Boston, Massachusetts, United States
• University of Missouri — Columbia, Missouri, United States
• Pulmonary and Allergy Associates of New Jersey — Summit, New Jersey, United States
• Jamaica Hospital Medical Center — Jamaica, New York, United States
• Columbia University — New York, New York, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Temple University — Philadelphia, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Dorn VA — Columbia, South Carolina, United States
• Virginia Commonwealth University — Richmond, Virginia, United States
• Overlake Hospital — Bellevue, Washington, United States
• University of Wisconsin — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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