Reducing Medical Risks in Individuals With Bipolar Disorder - Full Study

Completed · Not applicable

Conditions studied: Bipolar I Disorder

In brief

The primary aim of this project is to understand whether it is possible to reduce medical risk factors in adults with bipolar disorder and, in doing so, to improve psychiatric and functional outcomes. We will examine the role of behavioral risk factors and presumed behavioral mediators and moderators of health risk in individuals suffering from bipolar I disorder. The investigators will employ an innovative behavioral intervention with guideline based psychiatric care ( Integrated Risk Reduction Intervention - IRRI) in order to target modifiable medical risk factors.

Key facts

Study ID

NCT00746343

Run by

University of Pittsburgh

People needed

122

Starts

2008-09-01

Expected to finish

2013-09-01

Last updated by the study team

2013-12-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 to 55 years
• Body mass index (BMI) >25
• Meets DSM-IV criteria for lifetime bipolar I disorder
• Is in remission (with possible sub-threshold symptoms), i.e., as a HRDS-25 < or equal to 10, YMRS < or equal to 8, and CGI-BP-S <3 for two weeks
• Able to give basic informed consent
• Current diagnosis or past history of anxiety disorder, eating disorder, or other psychiatric comorbidities will not be exclusion criteria for participation, except those listed in the exclusion criteria below

You may not qualify if…

• Ultra-rapid cycling (>8 episodes per year) bipolar I disorder
• Presence of pervasive developmental disorder, antisocial personality disorder, current substance dependence or abuse, and organic mental disorder
• Unstable and severe medical illness that requires immediate and intensive medical attention, for instance, a subject with a terminal illness or a subject with severe and unstabilized coronary artery disease; these subjects will be immediately referred to the most appropriate medical and psychiatric treatment. When appropriate, the subjects can be reconsidered for inclusion in the study if/when their medical condition becomes compatible with participation in a protocol-driven research study
• Unwilling or unable to comply with study requirements (i.e., complete forms, attend scheduled evaluations)
• Not competent to provide informed consent in the opinion of the investigator
• Women who are planning to become pregnant, currently pregnant, or breast-feeding

Where it is running

• Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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