Oral L-Citrulline and ADMA in Pregnancy

Completed · Phase 1 · Has a placebo group

Conditions studied: Blood Pressure

In brief

The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to obese subjects will decrease the plasma ADMA/L-arginine ratio, lower maternal blood pressure, improve endothelial-dependent vascular function and peripheral vascular stiffness, and improve uterine artery Doppler resistance and flow.

Key facts

Study ID

NCT00743210

Run by

University of Pittsburgh

People needed

41

Starts

2010-01-01

Expected to finish

2013-06-01

Last updated by the study team

2014-07-16

Who can join

Age: 14 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Pre-pregnancy body mass index greater than or equal to 30kg/m2
• Primiparity
• Singleton pregnancy
• Gestational age at randomization between 10 and 14 weeks based on clinical information and evaluation of earliest ultrasound
• Maternal age between 14 and 40 years

You may not qualify if…

• chronic hypertension
• pregestational diabetes on medication (insulin, glyburide)
• major fetal anomaly or demise
• planned termination of the pregnancy
• collagen vascular disease (autoimmune disease) on medication
• renal disease
• epilepsy or other seizure disorder
• active or chronic liver disease
• heart disease
• cigarette smoker
• known illicit drug or alcohol abuse during current pregnancy
• already taking L-citrulline as a supplement (1gram/day or more)

Where it is running

• Magee-Womens Hospital of UPMC — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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