Effects of Low-dose Naltrexone in Combination With a Range of Smoked Marijuana

Completed · Phase 2 · Has a placebo group

Conditions studied: Marijuana Smoking

In brief

In heavy marijuana smokers, opioid receptor blockade increases the subjective and cardiovascular effects of marijuana. The current study was designed to clarify opioid-cannabinoid interactions by assessing how naltrexone shifts the dose-response function for marijuana-elicited effects in heavy marijuana smokers. For this within-subject, double-blind study, a marijuana smoking procedure was designed to characterize a dose-response relationship for marijuana's subjective and cardiovascular effects under blinded conditions.

Key facts

Study ID

NCT00743145

Run by

New York State Psychiatric Institute

People needed

23

Starts

2008-05-01

Expected to finish

2009-09-01

Last updated by the study team

2018-09-14

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current marijuana use
• Able to perform study procedures
• Women practicing an effective form of birth control

You may not qualify if…

• Current repeated illicit drug use (other than marijuana)
• Presence of significant medical illness (e.g., diabetes, cardiovascular disease,hypertension, hepatitis, clinically significant laboratory abnormalities, LFTs > 3x upper limit of normal, blood pressure > 140/90

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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