Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers

Completed · Phase 2 · Has a placebo group

Conditions studied: Pain Threshold, Mood

In brief

The following study is designed to determine the analgesic efficacy of smoked marijuana (0, 1.98, and 3.56% THC) and oral THC (0, 10, and 20 mg) in the Cold-Pressor Test (CPT), a laboratory model of pain which has predictive validity for clinical use of analgesics. Oral THC (dronabinol) is known to have a slower onset and longer duration of action compared with smoked marijuana. Therefore, the analgesic effects of oral THC is expected to peak later and last longer than effects produced by smoked marijuana.

Key facts

Study ID

NCT00743119

Run by

New York State Psychiatric Institute

People needed

34

Starts

2008-06-01

Expected to finish

2013-05-01

Last updated by the study team

2017-12-11

Who can join

Age: 21 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Adults between the ages of 21-45
• Current marijuana use
• Able to perform study procedures
• Women practicing an effective form of birth control

You may not qualify if…

• Female subjects who are currently pregnant or breastfeeding
• Current,repeated illicit drug use other than marijuana
• Presence of significant medical illness
• History of heart disease
• Request for drug treatment
• Current parole or probation
• Recent history of significant violent behavior

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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