The Effect of Fenoldopam in Solitary Partial Nephrectomy Surgery
Stopped early · Not applicable · Has a placebo group
Conditions studied: Partial Nephrectomy
In brief
This trial will study the effects of fenoldopam on renal function in patients who have a single kidney undergoing surgery to remove part of that kidney secondary to renal cell carcinoma. The investigators will monitor and evaluate throughout the perioperative course the kidney function. Normally kidney function is predicted to show a worsening followed by an improvement after surgery. The investigators want to specifically identify if the use of fenoldopam lessens the injury to the kidney with this surgery.
Key facts
- Study ID
- NCT00743106
- Run by
- The Cleveland Clinic
- People needed
- 90
- Starts
- 2002-09-01
- Expected to finish
- 2010-02-01
- Last updated by the study team
- 2018-09-19
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who have a solitary kidney and present for a partial nephrectomy
- Patients who have one atrophic minimally functioning kidney and present for partial nephrectomy on the other kidney
You may not qualify if…
- History of current renal disease beyond the diagnosis of renal malignancy
- Insulin dependent diabetes mellitus, myocardial infarction without subsequent coronary artery bypass or angioplasty
- History of congestive heart failure, renovascular occlusion greater than 45 minutes or less than 15 minutes, greater than one half of the solitary kidney resected
- A major perioperative complication that would potentially affect postoperative renal function (myocardial infarction, congestive heart failure, pulmonary embolus, massive hemorrhage and hypotension, ureteral obstruction or vascular thrombosis), and evidence of nephrotoxicity due to antibiotics
Where it is running
- Cleveland Clnic — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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