Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

Completed · Phase 1

Conditions studied: Sarcoma

In brief

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This clinical trial is studying the side effects and best dose of zoledronic acid when given together with combination chemotherapy in treating patients with newly diagnosed metastatic osteosarcoma.

Key facts

Study ID

NCT00742924

Run by

Children's Oncology Group

People needed

24

Starts

2008-08-01

Last updated by the study team

2014-07-04

Who can join

Age: any, up to 40. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital and Research Center Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Lucile Packard Children's Hospital Stanford University — Palo Alto, California, United States
• Rady Children's Hospital - San Diego — San Diego, California, United States
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• Nemours Children's Clinic - Orlando — Orlando, Florida, United States
• Sacred Heart Cancer Center at Sacred Heart Hospital — Pensacola, Florida, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
• Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States
• AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus — Atlanta, Georgia, United States
• Cancer Research Center of Hawaii — Honolulu, Hawaii, United States
• Mountain States Tumor Institute at St. Luke's Regional Medical Center — Boise, Idaho, United States
• Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
• Keyser Family Cancer Center at Advocate Hope Children's Hospital — Oak Lawn, Illinois, United States
• UAB Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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