A Crossover Study of the Acute Effects of Olanzapine in Healthy Volunteers

Completed · Not applicable · Has a placebo group

Conditions studied: Insulin Resistance, Diabetes Mellitus

In brief

The purpose of this clinical research study is to examine the acute hormonal and metabolic effects of the drug olanzapine, as well as appetite effects, in healthy volunteers. The hypotheses to be tested are that: (1) Olanzapine rapidly attenuates plasma leptin and (2) rapidly alters glucose tolerance in healthy volunteers. These questions will be answered by having volunteers undergo two glucose tolerance tests in a crossover study design.

Key facts

Study ID

NCT00741026

Run by

Milton S. Hershey Medical Center

People needed

15

Starts

2008-08-01

Expected to finish

2011-05-01

Last updated by the study team

2014-07-14

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy Volunteer
• Body Mass Index of 18.5-25 kilograms per square meter
• Must be able to swallow tablets
• Able to give informed consent

You may not qualify if…

• Any DSM-IV TR Axis I psychiatric disorder (except nicotine dependence)
• Presence of any medical disorder that may confound the assessment of relevant biologic measures, including: significant organ system dysfunction, metabolic diseases, type 1 diabetes mellitus, type 2 diabetes mellitus, pregnancy, endocrine disease, coagulopathy, clinically significant anemia, or acute infection
• Subjects who have taken any antipsychotic medication within the last 6 months
• Personal or family history of seizures and/or cardiac arrhythmias

Where it is running

• Penn State College of Medicine, Penn State Milton S. Hershey Medical Center — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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