Factors That Affect the Development of COPD Symptoms

Completed

Conditions studied: Pulmonary Disease, Chronic Obstructive

In brief

Chronic obstructive pulmonary disease (COPD) is the fourth most common cause of death in the United States. There is no cure and the disease gets worse over time. Although it usually occurs in people who smoke cigarettes, researchers do not know exactly how smoking leads to COPD. This study will compare blood and tissue samples from smokers and nonsmokers with and without COPD to determine why some COPD symptoms occur in some people and not others.

Key facts

Study ID

NCT00740337

Run by

Washington University School of Medicine

People needed

82

Starts

2007-10-01

Expected to finish

2016-02-01

Last updated by the study team

2018-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability to read and write in English
• Able to participate in the informed consent process
• Planned lung resection at BJH
• Acceptable pulmonary function tests done at BJH within 1 month of enrollment
• Acceptable chest CT scan done at BJH within 3 years of enrollment

You may not qualify if…

• Pregnant
• Prisoner
• Vulnerable populations
• Clinically significant lung disease other than COPD and the indication for resection (e.g., cystic fibrosis, bronchiectasis, obliterative bronchiolitis, airway lesion)
• Coexisting active chronic inflammatory or collagen vascular disease, immune deficiency of any kind, or previous organ transplant
• Known active hepatitis B, hepatitis C, or HIV/AIDS (not prospectively evaluated)
• Systemic chemotherapy within past 1 month (30 days)
• Hematologic malignancy or thoracic radiation within past year

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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